Anti-UPF3B

Anti-UPF3B
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-688A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A303-688A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop... more
Product information "Anti-UPF3B"
Protein function: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation, the function is independent of association with UPF2 and components of the EJC core. [The UniProt Consortium]
Keywords: Anti-UPF3B, Anti-hUpf3B, Anti-RENT3B, Anti-hUpf3p-X, Anti-Nonsense mRNA reducing factor 3B, Anti-Up-frameshift suppressor 3 homolog B, Anti-Regulator of nonsense transcripts 3B, Anti-Up-frameshift suppressor 3 homolog on chromosome X
Supplier: Bethyl Laboratories
Supplier-Nr: A303-688A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: rhesus monkey, gorilla, chimpanzee, crab-eating macaque, little brown bat, northern white-cheeked gibbon)
Immunogen: Synthetic peptide. The epitope recognized by A303-688A maps to a region between residue 300 and 350 of human Up-Frameshift Suppressor 3 Regulator of Nonsense Transcripts Homolog B using the numbering given in entry NP_542199.1 (GeneID 65109).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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