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Anti-UBB, clone 3C12

ART NR.: Pro-30317 (100 µg)

Hersteller: ProMab

Datenblatt

Anwendungen: WB, FC, ELISA

Format: purified

Klon: 3C12

Wirt: Mouse

Isotyp: IgG1

Reaktivität: human

Immunogen: Purified recombinant fragment of human UBB expressed in E. coli.

UniProt ID: P0CG47
Suche mit UniProt ID

Geninformationen: GeneID 7314

Schlagworte: Anti-UBB

Pro-30317

100 µg

292 €

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Bemerkungen: Purified antibody in PBS with 0.05% sodium azide and 0.5% protein stabilizer. Protein function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair, Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation, Lys-29-linked is involved in lysosomal degradation, Lys-33-linked is involved in kinase modification, Lys-48-linked is involved in protein degradation via the proteasome, Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. [The UniPro

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