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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A300-796A-T | 10 µl (2 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A300-796A | 100 µl | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central... more
Product information "Anti-TRF2"
Protein function: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo, plays a key role in telomeric loop (T loop) formation by generating 3' single- stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo, required to control the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres, thereby participating in to repressing homology- directed repair (HDR), which can affect telomere length. [The UniProt Consortium]
Keywords: | Anti-TERF2, Anti-TRBF2, Anti-Telomeric DNA-binding protein, Anti-TTAGGG repeat-binding factor 2, Anti-Telomeric repeat-binding factor 2 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A300-796A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: dog, pig, panda, rhesus monkey, gorilla, chimpanzee, crab-eating macaque, reeve's muntjac, barking deer, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide. The epitope recognized by A300-796A-M maps to a region between residue 375 and 425 of human Telomeric Repeat Binding Factor 2 using the numbering given in entry NP_005643.1 (GeneID 7014). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K11111 | Matching products |
UniProt ID : | Q15554 | Matching products |
Gene ID | GeneID 7014 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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