Anti-THOC2

Anti-THOC2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-630A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A303-630A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as... more
Product information "Anti-THOC2"
Protein function: Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC2 (and probably the THO complex) is involved in releasing mRNA from nuclear speckle domains. Required for NXF1 localization to the nuclear rim. Plays a role for proper neuronal development. [The UniProt Consortium]
Keywords: Anti-Tho2, Anti-THOC2, Anti-CXorf3, Anti-hTREX120, Anti-THO complex subunit 2
Supplier: Bethyl Laboratories
Supplier-Nr: A303-630A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: mouse)
Immunogen: Synthetic peptide. The epitope recognized by A303-630A maps to a region between residue 1543 to 1593 of human THO Complex 2 using the numbering given in entry NP_001075019.1 (GeneID 57187).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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