Anti-STAT2

Anti-STAT2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A303-510A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A303-510A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Signal transducer and activator of transcription that mediates signaling by... more
Product information "Anti-STAT2"
Protein function: Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121). [The UniProt Consortium]
Keywords: Anti-p113, Anti-STAT2, Anti-Signal transducer and activator of transcription 2
Supplier: Bethyl Laboratories
Supplier-Nr: A303-510A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan, gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by A303-510A maps to a region between residue 175 and 225 of human Signal Transducer and Activator of Transcription 2 using the numbering given in entry NP_005410.1 (GeneID 6773).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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