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Anti-​SET7 (IHC)
Rabbit
> sec. Ab
Pab IgG
human
Erklärungen der Abkürzungen ansehen.
antigen affinity purified IHCErklärungen der Abkürzungen ansehen. Bethyl
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IHC-​00616 100 µl

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Anti-SET7 (IHC)


Histone methyltransferase that specifically monomethylates 'Lys-​4' of histone H3. H3 'Lys-​4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-​1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-​histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-​[STA]-​K in substrate proteins. Monomethylates 'Lys-​189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-​372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-​mediated transcriptional activation. Also able to demethylated 'Lys-​372' of p53/TP53 in vitro.
Immunogen: The epitope recognized by IHC-​00616 maps to a region between residue 316 and 366 of human SET domain containing (lysine methyltransferase) 7 using the numbering given in entry NP_085151.1 (GeneID 80854).


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Kat #: IHC-00616


Menge:
100 µl

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Preis:
401 €

UniProt ID: Q8WTS6 (Protein knowledgebase)
Geninformationen: GeneID 80854

Antikörper-Konjugations-Kits

Schlagworte:
Anti-​SETD7, Anti-​SET7/9, EC=2.1.1.43, Anti-​KIAA1717, Anti-​H3-​K4-​HMTase SETD7, Anti-​Lysine N-​methyltransferase 7, Anti-​SET domain-​containing protein 7, Anti-​Histone H3-​K4 methyltransferase SETD7, Anti-​Histone-​lysine N-​methyltransferase SETD7, antibody, antibodies, Antikörper

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Products for: SETD7 - histone-lysine N-methyltransferase SETD7 [EC:2.1.1.43]



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