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Anti-SET7 (IHC)

ART NR.: IHC-00616 (100 µl)

Hersteller: Bethyl

Datenblatt

Anwendungen: IHC

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human

Immunogen: The epitope recognized by IHC-00616 maps to a region between residue 316 and 366 of human SET domain containing (lysine methyltransferase) 7 using the numbering given in entry NP_085151.1 (GeneID 80854).

UniProt ID: Q8WTS6
Suche mit UniProt ID

Geninformationen: GeneID 80854

Schlagworte: Anti-SETD7, Anti-SET7/9, EC=2.1.1.43, Anti-KIAA1717, Anti-H3-K4-HMTase SETD7, Anti-Lysine N-methyltransferase 7, Anti-SET domain-containing protein 7, Anti-Histone H3-K4 methyltransferase SETD7, Anti-Histone-lysine N-methyltransferase SETD7

100 µl

401 €

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Bemerkungen: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.

Spezifikationen

bethyl_datasheet_parse.php?nr=IHC-00616&ak=1
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