Anti-Proteasome (Prosome, Macropain) Inhibitor Subunit 1 (PI31, Proteasome Inhibitor Subunit 1 PI3-1

Anti-Proteasome (Prosome, Macropain) Inhibitor Subunit 1 (PI31, Proteasome Inhibitor Subunit 1 PI3-1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
P9078-81.100 100 µg - -

3 - 19 business days*

675.00€
 
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure... more
Product information "Anti-Proteasome (Prosome, Macropain) Inhibitor Subunit 1 (PI31, Proteasome Inhibitor Subunit 1 PI3-1"
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. , Recommended Dilutions: Peptide ELISA Titer: 1:32,000, Western Blot: 1-3ug/ml ~35kD band observed in Human Kidney lysates (calculated MW of 29.8kD according to NP_006805.2). In transfected HEK293 transiently expressing PSMF1 a band of approx. 35kD is observed. This band is not observed in the non-transfected HEK293., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-hPI31, Anti-Proteasome inhibitor PI31 subunit
Supplier: United States Biological
Supplier-Nr: P9078-81

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Species reactivity: human
Immunogen: Synthetic peptide corresponding to C-DHLPPPGYDDMYL, from the C Terminus of human PSMF1 (NP_006805.2).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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