Anti-PSME3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A303-879A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A303-879A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a... more

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Product information "Anti-PSME3"

Protein function: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978). [The UniProt Consortium]

Keywords:	Anti-PSME3, Anti-PA28g, Anti-PA28gamma, Anti-REG-gamma, Anti-Ki nuclear autoantigen, Anti-11S regulator complex subunit gamma, Anti-Proteasome activator 28 subunit gamma, Anti-Proteasome activator complex subunit 3
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-879A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse (Expected: chicken, pig, orangutan)
Immunogen:	Synthetic peptide. The epitope recognized by A303-879A maps to a region between residue 204 and 254 of human Proteasome (Prosome, Macropain) Activator Subunit 3 using the numbering given in entry NP_005780.2 (GeneID 10197).
Format:	Antigen Affinity Purified