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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
030562.100 | 100 µl | - | - |
3 - 19 business days* |
682.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
PRAK (p38-regulated /activated kinase), also referred to as mitogen-activated protein kinase... more
Product information "Anti-PRAK"
PRAK (p38-regulated /activated kinase), also referred to as mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK)-5, is an ubiquitously expressed serine/threonine kinase regulated by p38alpha and p38beta MAP kinases. Activated JNK, p38gamma or p38delta are unable to induce phosphorylation of PRAK in vitro. Phosphorylation of PRAK occurs in vivo in response to p38 activation by stress-related extracellular stimuli including UV light, oxidation and proinflammatory cytokines. Two other substrates for p38, MAPKAPK-2 and MAPKAPK-3/3pK, share approximately 45% sequence homology with PRAK including the phosphorylation motif recognized by p38, Lys-X-Thr-Pro. Activated PRAK has been shown to specifically phosphorylate HSP 27 in vitro, suggesting that the protein may play a role in stress-induced small heat shock protein phosphorylation in vivo. Applications: Western Bloting: 1:500-1:2000., Immunohistochemistry: 1:200-1:1000., ELISA: Suggested dilution 1:10000., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-MK5, Anti-PRAK, Anti-MK-5, Anti-MAPKAPK5, Anti-MAPKAPK-5, Anti-MAPKAP-K5, EC=2.7.11.1, Anti-MAPKAP kinase 5, Anti-MAPK-activated protein kinase 5, Anti-MAP kinase-activated protein kinase 5, Anti-p38-regulated/activated protein kinase |
Supplier: | United States Biological |
Supplier-Nr: | 030562 |
Properties
Application: | ELISA, IHC, WB |
Antibody Type: | Monoclonal |
Clone: | 13B640 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Purified recombinant fragment of PRAK expressed in E. coli. |
Database Information
KEGG ID : | K04442 | Matching products |
UniProt ID : | Q8IW41 | Matching products |
Gene ID | GeneID 8550 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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