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Anti-PR Set7 (SET8, SET Domain Containing 8, SET Domain-containing Protein 8, SET Domain Containing Lysine Methyltransferase 8, SET Domain-containing (Lysine Methyltransferase) 8, SETD8, H4 K20 Specific Histone Methyltransferase, H4-K20-HMTase SETD8, PR/S

ART NR.: P5575-01B.100 (100 µl)

Hersteller: USBio

Datenblatt

Anwendungen: WB, ICC

Format: affinity purified

Wirt: Rabbit

Reaktivität: human

Immunogen: GST-tagged recombinant protein corresponding to human SETD8 (hPR-SET7).

UniProt ID: Q9NQR1
Suche mit UniProt ID

Geninformationen: GeneID 387893

Schlagworte: Anti-KMT5A, EC=2.1.1.-, EC=2.1.1.43, Anti-PR-Set7, Anti-Lysine N-methyltransferase 5A, Anti-SET domain-containing protein 8, Anti-N-lysine methyltransferase SETD8, Anti-PR/SET domain-containing protein 07, Anti-Histone-lysine N-methyltransferase SETD8

P5575-01B.100

100 µl

667 €

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Bemerkungen: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. [The UniProt Consortium]

Spezifikationen

usbio_datasheet_parse.php?nr=P5575-01B.100&ak=1
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