The SMARCs (SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin), and BAFs (BRG1-associated factors), have been identified as components of the mammalian SWI/SNF-like chromatin-remodeling protein complexes. These multi-protein complexes are proposed to function as ATP-driven motors that translocate along DNA and destabilize nucleosomal structures to facilitate transcription factor binding. PB1/BAF180 is a component of the SWI/SNF-B (PBAF) complex. It contains six bromodomains which are defined by a 110 amino-acid module that interacts with acetylated lysine and is found in many chromatin binding proteins and histone acetyltransferases. PB1/BAF180 has been proposed to function as a tumor suppressor protein. Recently, PB1/BAF180 has been found to play a role in mediating cell cycle arrest in response to DNA damage via the regulation of the tumor suppressor p21. Alternate names for PB1/BAF180 include protein polybromo-1, polybromo-1D, BRG1-associated factor 180, hPB1, and PBRM1.
Immunogen: synthetic peptide. The epitope recognized by A301-590A maps to a region between residue 1 and 50 of human polybromo 1 (BRG1-associated factor 180) using the numbering given in entry AAP34197.1 (GeneID 55193).
Kat #: A301-590A
Menge: 100 µl
Preis: 349 €
UniProt ID: Q86U86 (Protein knowledgebase)
Anti-PB1, Anti-PB-1, Anti-polybromo 1, Anti-BAF180, Anti-BAF-180, Anti-BRG1-associated factor 180., antibody, antibodies, Antikörper
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Products for: PBRM1, PB1 - protein polybromo-1