Anti-PARP, clone 194C1439

Anti-PARP, clone 194C1439
Item number Size Datasheet Manual SDS Delivery time Quantity Price
200-301-I03 100 µg - -

6 - 10 business days*

713.00€
 
Anti-PARP Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest... more
Product information "Anti-PARP, clone 194C1439"
Anti-PARP Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Anti-PARP from human based on 100% homology with the immunizing sequence. Cross-reactivity with Anti-PARP from other sources has not been determined. Protein function: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Required for PARP9 and DTX3L recruitement to DNA damage sites. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. [The UniProt Consortium]
Keywords: Anti-PARP1, Anti-ARTD1, Anti-ADPRT, Anti-PARP-1, Anti-ADPRT 1, EC=2.4.2.30, Anti-Poly[ADP-ribose] synthase 1, Anti-Poly [ADP-ribose] polymerase 1, Anti-NAD(+) ADP-ribosyltransferase 1, Anti-ADP-ribosyltransferase diphtheria toxin-like 1
Supplier: Rockland Immunochemicals
Supplier-Nr: 200-301-I03

Properties

Application: FC, WB
Antibody Type: Monoclonal
Clone: 194C1439
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: peptide containing amino acids near the 214/215 cleavage site of human PARP protein.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-PARP, clone 194C1439"
Write a review
or to review a product.
Viewed