Anti-NPM1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-404A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A302-404A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Involved in diverse cellular processes such as ribosome biogenesis, centrosome... more
Product information "Anti-NPM1"
Protein function: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double- stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029). [The UniProt Consortium]
Keywords: Anti-NPM, Anti-NPM1, Anti-Numatrin, Anti-Nucleophosmin, Anti-Nucleolar protein NO38, Anti-Nucleolar phosphoprotein B23
Supplier: Bethyl Laboratories
Supplier-Nr: A302-404A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: rat, bovine)
Immunogen: synthetic peptide. The epitope recognized by A302-404A maps to a region between residue 250 and 294 of human nucleophosmin using the numbering given in entry NP_002511.1 (GeneID 4869).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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