6 products were found matching "Cay14219-500"!

Ubiquitin is a small protein composed of 76 amino acids and having a molecular weight of 8.6 kDa. It exists in all eukaryotic cells and is responsible for numerous functions in the cell by post-translational modifications of substrate proteins (ubiquitination). This process is important to numerous cellular...

5-trans PGE2 occurs naturally in some gorgonian corals and is a common impurity in commercial lots of PGE1. It is 18 times more potent than PGE2 in activating adenylate cyclase in NCB-20 cell homogenates. 5-trans PGE2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen...

Hygromycin B is an aminoglycoside antibiotic that has been found in S. hygroscopicus. It is active against E. coli (MIC = 150 µg/ml) and cytotoxic to both prokaryotic and eukaryotic cells via inhibition of protein synthesis. Hygromycin B has commonly been used in molecular and cell biology applications to select for...

10(S)-PAHSA is a stereoisomer of 10-PAHSA (Cay-19973), an endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid (Cay-10006627) is esterified to 10-hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most...

11beta-PGE2 is the C-11 epimer of PGE2. It is a moderate inhibitor of PGE2 binding to rat hypothalamic membranes with a Ki value of 53 nM. 11beta-PGE2 also stimulates bone resorption in rats at concentrations of 10 to 1,000 nM which is similar to PGE2. 11beta-PGE2 inhibits PGE2 binding to the prostaglandin...

Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Cay-11694). Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay....