Anti-MBD1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
BPS-25303	50 µg		-	-	3 - 15 business days*		873.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at... more

Close menu

Product information "Anti-MBD1"

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.

Keywords:	Anti-CXXC3, Anti-Methyl-CpG-binding protein MBD1, Anti-CXXC-type zinc finger protein 3, Anti-Methyl-CpG-binding domain protein 1, Anti-Protein containing methyl-CpG-binding domain 1,
Supplier:	BPS Bioscience
Supplier-Nr:	25303

Properties

Application:	ChIP, ELISA, WB
Antibody Type:	Polyclonal
Conjugate:	No
Species reactivity:	human
Immunogen:	human MBD1 (Methyl CpG binding domain protein 1), using a KLH conjugated synthetic peptide containing a sequence from the N terminal part of the protein.
Format:	Affinity Purified