Anti-Ku80

Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-627A-T 10 µl (2 µg) -

2 - 8 business days*

164.00€
A302-627A 100 µl -

2 - 8 business days*

588.00€
 
Protein function: Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome... more
Product information "Anti-Ku80"
Protein function: Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together (PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488). The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer binds to the osteocalcin promoter and activates osteocalcin expression (PubMed:20383123). The XRCC5/6 dimer probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose- 5-phosphate at an abasic site near double-strand breaks. XRCC5 probably acts as the catalytic subunit of 5'-dRP activity, and allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription (PubMed:8621488). Plays a role in the regulation of DNA virus- mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. [The UniProt Consortium]
Keywords: Anti-Ku80, Anti-Ku86, Anti-TLAA, Anti-G22P2, Anti-CTC85, Anti-CTCBF, Anti-XRCC5, EC=3.6.4.-, Anti-Nuclear factor IV, Anti-DNA repair protein XRCC5, Anti-Thyroid-lupus autoantigen, Anti-86 kDa subunit of Ku antigen, Anti-Lupus Ku autoantigen protein p86
Supplier: Bethyl Laboratories
Supplier-Nr: A302-627A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: gorilla, chimpanzee)
Immunogen: synthetic peptide. The epitope recognized by A302-627A maps to a region between residue 150 and 200 of human Lupus Ku autoantigen protein p86 using the numbering given in entry NP_066964.1 (GeneID 7520).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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