25 products were found matching "I7661-32A.50"!

Integrin alpha V beta 3 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to alpha V beta 3 integrin. A tissue detergent extract, which was applied to the column was prepared as previously described (1). It has tested negative for HIV & Hepatitis. Applications:...

Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake, thereby mediating the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). This protein can activate PI3K either...

Integrin alphaLbeta2 is one of three beta2 integrin adhesion proteins. The non-covalent heterodimer of 180kD aL/CD11a and 95kD b2/CD18 integrin subunits is expressed on virtually all leukocytes. The ligand binding site of LFA-1 is in the N-terminal head region, formed by an interaction of the vWFA (I, I-like)...

Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this...

Integrin a11B1 is a noncovalent, heterdimeric collagen receptor that contains a 150kD a11 subunit complexed to a 130kD B1/CD29 subunit. a11B1 is the only known a11-containing integrin. By contrast, at least twelve a-integrins share the B1 subunit. a11B1 is expressed on fibroblasts from cornea, skin and periodontal...

Applications: , Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin sections): 10ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid...

Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor...

CD29 is a 130kD protein, also known as integrin b1, VLA-b chain, or GPIIa. It is a member of the integrin family, expressed broadly on leukocytes, endothelial cells, smooth muscle, and epithelial cells. In association with CD49a-f, CD29 forms the VLA-1 through VLA-6 complexes, respectively. It plays an important...

Integrin alphaV beta5 was purified from human placenta by affinity chromatography using immobilized monoclonal antibodies to alphaV beta5 integrin. Interacts with vitronectin in ELISA. Applications: Suitable for use in Electrophoresis, Immunoblot (non-reducing) and Ligand Binding studies. Other applications have...

Integrin aVB1 is one of five aV and twelve B1 containing Integrin family adhesion receptor heterodimers. The non-covalent heterodimer of 170kD aV and 130kD B1/CD29 is present on cells that express both subunits, and dimer formation is dependent on the availability of the individual subunits. Since the aV and B1...

The involvement of integrins in vascular proliferation, adhesion and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and...

Integrin alpha 8 is a 170-200kD member of the Integrin family of adhesion molecules. It forms an exclusive noncovalent heterodimer with Integrin b1. Alpha8beta1 promotes both cell adhesion and survival and is known to bind to fibronectin, the latency-associated peptide in latent TGFb1 and nephronectin. Mouse...