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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
I3000-26A.100 | 100 µg | - | - |
3 - 19 business days* |
826.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
IKKbeta is a member of the IKK complex which is composed of IKKalpha, IKKbeta, IKKgamma and IKAP.... more
Product information "Anti-IKK beta (IkappaB Kinase beta, IKKb, IKK2)"
IKKbeta is a member of the IKK complex which is composed of IKKalpha, IKKbeta, IKKgamma and IKAP. IkB Kinase (IKK) complex is a critical component in NFkB regulation. In a majority of unstimulated cells, the NFkB transcription factors exist in their inactive form and are retained in the cytoplasm by the bound inhibitory IkB proteins. For NFkB to become activated, it must first disassociate from the inhibitor IkB. This occurs via the serine phosphorylation of IkB on Ser32 and Ser36. Post receptor stimulation, most notably by TNFalpha, NIK, a serine/threonine kinase, becomes activated and phosphorylates IKKalpha and IKKbeta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKKbeta autophosphorylates, which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKKbeta activity can also be regulated by MEKK-1. IKK then binds to and phosphorylates IkBalpha on the two serine residues. This phosphorylation marks IkB for ubiquination and destruction by the proteosome. This free the NFkB complex and allows it to translocates to the nucleus. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:500-1:1000 (1ug/ml), Immunohistochemistry (Paraffin): 1ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: A431 cell lysate, HeLa cells, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-IKBKB, Anti-IKK-B, Anti-IkBKB, EC=2.7.11.10, Anti-NFKBIKB, Anti-IKK-beta, Anti-I-kappa-B kinase 2, Anti-I-kappa-B-kinase beta, Anti-Nuclear factor NF-kappa-B inhibitor kinase beta, Anti-Inhibitor of nuclear factor kappa-B kinase subunit beta |
Supplier: | United States Biological |
Supplier-Nr: | I3000-26A |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Synthetic peptide corresponding to aa662-680 of human IKK-beta (3,4), which differs from the corresponding murine sequence by one amino acid. Cellular Localization: Cytoplasm. |
Format: | Purified |
Database Information
KEGG ID : | K07209 | Matching products |
UniProt ID : | O14920 | Matching products |
Gene ID | GeneID 3551 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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