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Antikörper Treffer 1
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Name/Antigen KLON WIRT TYP ISOTYP SPEZ. REAKT. FORMAT ANWENDUNG HERSTELLER KAT # MENGE PREIS










Anti-​IKBKB, clone 10A2C5B3
10A2C5B3 Mouse
> sec. Ab
Mab IgG1
human
Erklärungen der Abkürzungen ansehen.
ascites WB
IHC
ELISAErklärungen der Abkürzungen ansehen.
ProMab
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Pro-​20114

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100 µl

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301 €
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Anti-IKBKB, clone 10A2C5B3


Ascitic fluid containing 0.03% sodium azide. Protein function: Serine kinase that plays an essential role in the NF-​ kappa-​B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-​kappa-​B activation and phosphorylates inhibitors of NF-​kappa-​B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-​kappa-​B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-​kappa-​B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-​kappa-​B subunits RELA and NFKB1, as well as IKK-​related kinases TBK1 and IKBKE. IKK-​related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-​induced NF-​kappa-​B activation. [The UniProt Consortium]
Immunogen: Purified recombinant fragment of IKBKB expressed in E. coli.


Datenblatt ansehen

Kat #: Pro-20114


Menge:
100 µl

Buy Bulk


Preis:
301 €

UniProt ID: O14920 (Protein knowledgebase)
Geninformationen: GeneID 3551

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Schlagworte:
Anti-​IKK2, Anti-​IKKB, Anti-​IKBKB, Anti-​IKK-​B, Anti-​IkBKB, Anti-​NFKBIKB, Anti-​IKK-​beta, EC=2.7.11.10, Anti-​I-​kappa-​B kinase 2, Anti-​I-​kappa-​B-​kinase beta, Anti-​Nuclear factor NF-​kappa-​B inhibitor kinase beta, antibody, antibodies, Antikörper

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Products for: IKBKB, IKKB - inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]




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