Antikörper Anti-IKBKB, clone 10A2C5B3

Antikörper Treffer 1

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Name/Antigen	KLON	WIRT	TYP	ISOTYP	SPEZ. REAKT.	FORMAT	ANWENDUNG	HERSTELLER	KAT #	MENGE	PREIS

Anti-IKBKB, clone 10A2C5B3	10A2C5B3	Mouse > sec. Ab	Mab	IgG1	human	ascites	WB IHC ELISA	ProMab	Pro-20114	100 µl Buy Bulk	274 €
Ascitic fluid containing 0.03% sodium azide. Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. [The UniProt Consortium] Immunogen: Purified recombinant fragment of IKBKB expressed in E. coli. Datenblatt ansehen Kat #: Pro-20114 Menge: 100 µl Buy Bulk Preis: 274 € UniProt ID: O14920 (Protein knowledgebase) Geninformationen: GeneID 3551 Passende, verwandte Produkte Antikörper-Konjugations-Kits Schlagworte: Anti-IKK2, Anti-IKKB, Anti-IKBKB, Anti-IKK-B, Anti-IkBKB, Anti-NFKBIKB, Anti-IKK-beta, EC=2.7.11.10, Anti-I-kappa-B kinase 2, Anti-I-kappa-B-kinase beta, Anti-Nuclear factor NF-kappa-B inhibitor kinase beta, antibody, antibodies, Antikörper Loading ... zurück							Weitere Produkte für dieses Protein: Antibodies Anti-IKBKB, Kat #: WA-AO1090a Anti-IKBKB, Kat #: WA-AO1090b Anti-IKBKB (C), Kat #: AC-R1338-2 Anti-IKBKB, clone 10A2, Kat #: Pro-20113 Anti-IKK beta, Kat #: WA-AM8109b Anti-IKK beta, Kat #: WA-AM8109b.20 Anti-IKK beta, Kat #: WA-AP8109a Anti-IKK beta, Kat #: WA-AP8109a.20 Anti-IKK beta, Kat #: WA-AM8109a Anti-IKK beta, Kat #: WA-AM8109a.20 more siRNA IKBKB predesign siRNA, Kat #: WA-RI12677 Chemicals & More IKBKB Over-expression Lysate, Kat #: WA-LY10108a Peptides Phospho-IKKb-Y199 Antibody Blocking Peptide, Kat #: WA-BP3127a Relevant Pathways: MAPK signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway mTOR signaling pathway Apoptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway T cell receptor signaling pathway B cell receptor signaling pathway Neurotrophin signaling pathway Insulin signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Epithelial cell signaling in Helicobacter pylori infection Shigellosis Chagas disease (American trypanosomiasis) Toxoplasmosis Hepatitis C Influenza A HTLV-I infection Herpes simplex infection Epstein-Barr virus infection Pathways in cancer Pancreatic cancer Prostate cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Products for: IKBKB, IKKB - inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10] Antibodies (54) Chemicals & More (7) Peptides (1) siRNA (1)

Datenbank vom 14.06.2013, 14:39 Uhr

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