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Anti-IKBKB, clone 10A2C5B3

ART NR.: Pro-20114 (100 µl)

Hersteller: ProMab

Datenblatt

Anwendungen: WB, IHC, ELISA

Format: ascites

Klon: 10A2C5B3

Wirt: Mouse

Isotyp: IgG1

Reaktivität: human

Immunogen: Purified recombinant fragment of IKBKB expressed in E. coli.

UniProt ID: O14920
Suche mit UniProt ID

Geninformationen: GeneID 3551

Schlagworte: Anti-IKK2, Anti-IKKB, Anti-IKBKB, Anti-IKK-B, Anti-IkBKB, Anti-NFKBIKB, Anti-IKK-beta, EC=2.7.11.10, Anti-I-kappa-B kinase 2, Anti-I-kappa-B-kinase beta, Anti-Nuclear factor NF-kappa-B inhibitor kinase beta

100 µl

301 €

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Bemerkungen: Ascitic fluid containing 0.03% sodium azide. Protein function: Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation. [The UniProt Consortium]

Die Preise für Antikörper verstehen sich exkl. Versandkosten, eventuell anfallender Kühlmittelpauschale sowie der jeweils geltenden Mehrwertsteuer.





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