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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
I7661-18U.50 | 50 µg | - | - |
3 - 19 business days* |
425.00€
|
||
I7661-18U.100 | 100 µg | - | - |
3 - 19 business days* |
540.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor... more
Product information "Anti-IGF1R (Insulin-like Growth Factor 1 Receptor, Insulin-like Growth Factor I Receptor, IGF-I Rece"
Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The IR and IGF-1R are heterotetrameric proteins consisting of two ligand-binding a subunits and two b subunits that each contain a tyrosine kinase domain. Insulin/IGF-1 binding to the extracellular domain leads to auto-phosphorylation of the receptor and activation of the intrinsic tyrosine kinase activity, leading to tyrosine phosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. The catalytic loops within the tyrosine kinase domains of the IR/IGF1R contain a three tyrosine motif corresponding to tyrosines 1158, 1162 and 1163 (for the IR) and 1131, 1135 and 1136 (for the IGF1R). It is generally believed that autophosphorylation within the activation loop proceeds in a processive manner initiating at the second tyrosine (1162 or 1135), followed by phosphorylation at the first tyrosine (1158 or 1131), then the last (1163 or 1136), upon which the IR or IGF1R becomes fully active. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | EC=2.7.10.1, Anti-IGF-I receptor, Anti-Insulin-like growth factor 1 receptor, Anti-Insulin-like growth factor I receptor, Anti-Insulin-like growth factor 1 receptor beta chain, Anti-Insulin-like growth factor 1 receptor alpha chain |
Supplier: | United States Biological |
Supplier-Nr: | I7661-18U |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthetic non-phosphopeptide corresponding to human IGF-1R around the phosphorylation site of tyrosine 1280 (S-F-YP-Y-S). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05087 | Matching products |
UniProt ID : | P08069 | Matching products |
Gene ID | GeneID 3480 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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