- Search results for Cay16641
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13 products were found matching "Cay16641"!
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Item number: Cay16644-1
Porcupine (PORCN) is a membrane bound O-acyltransferase that mediates palmitoylation of Wnt family proteins. This step is required for secretion and biologic activity of Wnt proteins, which have roles in embryonic development and cancer. Wnt-C59 is a potent inhibitor of PORCN, as measured by prevention of Wnt3A...
Keywords: | PORCN Inhibitor II, 4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]-benzeneacetamide |
Application: | Porcupine inhibitor |
CAS | 1243243-89-1 |
MW: | 379.5 D |
From 60.00€
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Item number: Cay11664-1
Forskolin (Cay-11018) is a naturally-occurring diterpene that activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. 1,9-dideoxy Forskolin is an analog of forskolin that interacts with, but does not activate,...
Keywords: | (3R,4aS,5S,6S,6aS,10aS,10bR)-5-(acetyloxy)-3-ethenyldodecahydro-6-hydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-... |
Application: | Adenylate cyclase binding |
CAS | 64657-18-7 |
MW: | 378.5 D |
From 77.00€
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Item number: Cay16641-100
Goat Anti-Human IgG Fcgamma fragment specific conjugated to SureLight(TM) R-PE Antibody: Goat polyclonal Anti-Human IgG, Fc-fragment specific Uses: Flow cytometry, Fluorescence-activated cell sorting, Luminex, and Protein MicroarraysEmission: 578 nm. Excitation: 565>498 nm. Formulation: (Request formulation change),...
Application: | Cell based assays, FC |
Host: | Goat |
Species reactivity: | human |
From 148.00€
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Item number: Cay16411-100
beta-Nicotinamide mononucleotide (beta-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+, Cay-16077). Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to generate beta-NMN, which is subsequently...
Keywords: | beta-NMN, 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-pyridinium, inner salt |
Application: | NAD biosynthesis intermediate |
CAS | 1094-61-7 |
MW: | 334.2 D |
From 60.00€
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Item number: Cay16441-1
SMYD2 is a lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53 and retinoblastoma-associated protein. LLY-507 is a cell-active, small molecule inhibitor of SMYD2 (IC50 = 15 nM). It has been shown to inhibit p53 lysine370 monomethylation in KYSE-150 esophageal squamous...
Keywords: | 5-cyano-2'-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]-1-piperazinyl]-N-[3-(1-pyrrolidinyl)propyl]-[1,1'-biphenyl]-3-carboxamide |
Application: | SMYD2 inhibitor |
CAS | 1793053-37-8 |
MW: | 574.8 D |
From 77.00€
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Item number: Cay16643-1
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling. Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi. SB-590885 is a potent inhibitor of B-Raf (Kd = 0.3 nM). It less effectively inhibits c-Raf (Ki =...
Keywords: | 5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime |
Application: | Potent B-Raf inhibitor |
CAS | 405554-55-4 |
MW: | 453.5 D |
From 66.00€
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Item number: Cay16645-1
4-Methylumbelliferyl Phosphate (4-MUP) is a fluorogenic substrate for phosphatases, including acid and alkaline phosphatases. It is converted to the fluorescent product 4-methylumbelliferone (4-MU), which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at...
Keywords: | 4-Methylumbelliferone Phosphate, 4-MU Phosphate, 4-MUP, 7-hydroxy-4-Methylcoumarin Phosphate,... |
Application: | Phosphatase fluorogenic substrate |
CAS | 3368-04-5 |
MW: | 256.2 D |
From 39.00€
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Item number: Cay16642-1
Goat anti-mouse IgG (H+L) conjugated to SureLight(TM) R-PE Antibody: Goat polyclonal anti-Mouse IgG (minimally reactive toward rabbit, bovine serum proteins) Dye: SureLight(TM) R-phycoerythrin (R-PE) Excitation max. lambda: 565>498 nm Emission max. lambda: 578 nm Uses: Flow cytometry, Fluorescence-activated cell...
Application: | Cell based assays, FC |
Host: | Goat |
Species reactivity: | mouse |
From 148.00€
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Item number: Cay16624-1
GPR120 (free fatty acid receptor 4/FFAR4) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. It has been linked to the ability of fatty acids to produce anti-inflammatory effects and to acutely potentiate insulin...
Keywords: | GPR120 cpdA, 3-[2-chloro-5-(trifluoromethoxy)phenyl]-3-azaspiro[5.5]undecane-9-acetic acid |
Application: | GPR120 agonist |
CAS | 1599477-75-4 |
MW: | 405.8 D |
From 43.00€
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Item number: Cay16604-1
Nicotinamide is a precursor of NAD (Cay-16077) and NADP (Cay-10004675), which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide...
Keywords: | N1-Methylnicotinamide chloride, Nicotinamide methochloride, Trigonellamide chloride,... |
Application: | Primary nicotinamide metabolite |
CAS | 1005-24-9 |
MW: | 172.6 D |
From 43.00€
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Item number: Cay16464-1
alpha-D-Glucose-1,6-bisphosphate is a bis-phosphorylated derivative of alpha-D-glucose that has roles in carbohydrate metabolism. It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. It is...
Keywords: | D-Glucose-1,6-diphosphate, Glc-1,6-P2, alpha-D-glucopyranose, 1,6-bis(dihydrogen phosphate), cyclohexanamine (1:4), hydrate |
Application: | alpha-/beta-phosphoglucomutase / hexoglucomutase identification, differentiation, characterization |
MW: | 736.8 D |
From 60.00€
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Item number: Cay16264-1
LY2940680 is a smoothened (Smo) antagonist. It inhibits [35S]GTPgammaS binding in CHO cells expressing wild-type Smo (IC50 = 294 nM) and reduces production of GLI1 mRNA induced by sonic hedgehog (Shh) in Daoy cells (IC50 = 5.49 nM). Topical application of LY2940680 (2% w/v) decreases skin GLI1 and PTCH1 mRNA...
Keywords: | Taladegib, 4-fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4-piperidinyl]-2-(trifluoromethyl)-benzamide |
Application: | Smo inhibitor |
CAS | 1258861-20-9 |
MW: | 512.5 D |
From 82.00€
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