Autoantibodies to histone antigens have been described in patients with idiopathic and drug-induced SLE, rheumatoid arthritis, and other conditions. The presence of autoantibodies to histones are frequently found in several rheumatic disorders (1). In one study, the predominant responses to histones in SLE sera were...

Applications: , Suitable for use in Western Blot and ChIP. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:5000 dilution of this lot detected acetyl-Histone H4 (Lys5) in acid extracts from sodium butyrate treated HeLa cells , ChIP: An independent laboratory has shown that this antibody...

Applications:, Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:100-1:500, ELISA: 1:1000, Western Blot: 1:500-1:1000, Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml, Optimal dilutions to...

Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core, histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin (1). The N-terminal tail of core histones undergoes different post-translational...