Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin (1). The amino-terminal tails of core histones undergo various posttranslational...

Histone H2A is the core component of the nucleosome. It is involved in nucleosome wrapping and compacting of DNA into chromatin, limiting DNA's accessibility to the cellular machinery. Histones thereby play a central role in transcription regulation, DNA repair, replication, and chromosomal stability. DNA...