104 products were found matching "H5110-02D"!

Histone H1 is located in the nuclear and is necessary for the condensation of nucleosome chains into higher order structures. Applications: Suitable for use in Western Blot and tissue or cell immunostaining. Other applications not tested. Recommended Dilution: Western Blot: 1:250-1:500, Tissue Staining: 1:100, Cell...

Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin (1). The N-terminal tail of core histones undergoes different post-translational...

Applications: , Suitable for use as a substrate for histone-modifying enzymes. Other applications not tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding...

Histone macroH2A1 and macroH2A2 comprise a family of variant histone H2A proteins. MacroH2A1 exists as two distinct isoforms due to alternative splicing of a single gene, macroH2A1.1 levels accumulate throughout differentiation and development while macroH2A1.2 shows a constant level of expression (1). MacroH2A1 and...

Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin (1). The N-terminal tail of core histones undergoes different post-translational...

Histone H2A.X is a variant histone that represents approximately 10% of the total H2A histone proteins in normal human fibroblasts (1). H2A.X is required for checkpoint-mediated cell cycle arrest and DNA repair following double-stranded DNA breaks (1). DNA damage, caused by ionizing radiation, UV-light, or...

The nucleosome is made up of four core histone proteins (H2A, H2B, H3 and H4) and is the primary building block of chromatin. The core histones form an octamer which is made up of one H3-H4 tetramer and two H2A-H2B dimers. The C-terminal domains of the core histones have very similar conformations that are important...

Changes in chromatin structure play a key role in the regulation of transcription in eukaryotes. The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4. Acetylation of core histones regulates gene expression. Histone H2B is acetylated in the...

Autoantibodies to histone antigens have been described in patients with idiopathic and drug-induced SLE, rheumatoid arthritis, and other conditions. Histones are a group of similar, small, highly conserved nuclear proteins that bind to DNA by their many basic residues. The presence of autoantibodies to histones are...

In diploid eucaryotic cells, the chromatin fibers are about 20nM in diameter. They consist of two major components in equal amounts, DNA and the basic proteins call Histones. The recurring positive charges of the histones form electrostataic associations with the negatively charged phosphate groups of DNA making the...

The histone proteins serve as a structural scaffold for the organization of nuclear DNA into chromatin. In eukaryotic cells there are 4 core histone proteins, H2A, H2B, H3 and H4 that assemble to form an octamer round which the DNA is wrapped in a sequence dependent manner. The resulting complex is known as a...

Applications:, Suitable for use in ELISA, Western Blot, Immunocytochemistry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunocytochemistry: Paraformaldehyde or acteone fixed cell preparations, Immunohistochemistry: Paraformaldehyde or acteone fixed frozen sections. Formalin fixed,...