Hepatocyte Growth Factor (HGF) is also known as Scatter Factor (SF) or Hepatopoietin A. Membrane receptor for HGF/SF is the product of the proto-oncogene c-met, a tyrosine kinase. HGF/SF is a pleiotropic growth factor which is produced by mesodermally derived cells, such as Kupffer cells/macrophages, endothelial...

Pro-HGF-A is a 96kD member of the PA-FXII-HGFA family of enzymes. It is secreted by hepatocytes and is found in plasma at ~40nM concentration. Other cells selectively reported to express HGF-A include astrocytes, endothelium, fibroblasts and macrophages. Upon activation, HGF-A is known to activate both proHGF and...

Human hepatocyte growth factor receptor, (HGF R), a product of the proto-oncogene c-MET, is a heterodimeric transmembrane glycoprotein that is a receptor-type tyrosine kinase. HGF R is synthesized as a 1390 aa single-chain precursor which undergoes cotranslational glycosylation and proteolytic cleavage to give rise...

Hepatocyte Growth Factor (HGF) is structurally similar, but not identical to scatter factor, a molecule shown to stimulate the dissociation and scattering of epithelial cells. It mapped to 7q21.1 and is involved in liver regeneration. Human HGF has been purified approximately 209,000-fold with 18% yield from plasma...

Hepatocyte growth factor or scatter factor, is a member of the plasminogen related growth factor family. Members are potent effectors of growth, movement and differentiation of epithelial and endothelial cells. HGF/SF may exhibit morphogenesis in adjacent cells. The membrane receptor for HGF/SF is the product of the...