Anti-HDAC1

Anti-HDAC1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A300-712A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A300-712A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of... more
Product information "Anti-HDAC1"
Protein function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST- mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation. [The UniProt Consortium]
Keywords: Anti-HD1, Anti-HDAC1, Anti-RPD3L1, EC=3.5.1.98, Anti-Histone deacetylase 1
Supplier: Bethyl Laboratories
Supplier-Nr: A300-712A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: orangutan)
Immunogen: synthetic peptide. The epitope recognized by A300-712A maps to the N-terminus of human Histone Deacetylase 1 using the numbering given in entry NP_004955.2 (GeneID 3065).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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