Anti-H2AX

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A303-837A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A303-837A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.... more

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Product information "Anti-H2AX"

Protein function: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. [The UniProt Consortium]

Keywords:	Anti-H2AX, Anti-H2AFX, Anti-H2a/x, Anti-Histone H2AX, Anti-Histone H2A.X
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-837A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Goat
Species reactivity:	human, mouse (Expected: rabbit, rhesus monkey, gorilla, crab-eating macaque)
Immunogen:	Synthetic peptide. The epitope recognized by A303-837A maps to the C-terminus of human Histone H2AX using the numbering given in entry P16104 (GeneID 3014).
Format:	Antigen Affinity Purified