Anti-Granulin (GRN, GEP, GP88, PCDGF, PEPI, PGRN, PC cell-derived growth factor, acrogranin, granuli

Anti-Granulin (GRN, GEP, GP88, PCDGF, PEPI, PGRN, PC cell-derived growth factor, acrogranin, granuli
Item number Size Datasheet Manual SDS Delivery time Quantity Price
G8944-50B.100 100 µg - -

3 - 19 business days*

675.00€
 
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single... more
Product information "Anti-Granulin (GRN, GEP, GP88, PCDGF, PEPI, PGRN, PC cell-derived growth factor, acrogranin, granuli"
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88,000 Da precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6,000 Da peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. GRN is expressed in myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. present in inflammatory cells and bone marrow. highest levels in kidney. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000, Western Blot: 1-3ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: A549 and HeLa , Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-Granulins, Anti-Granulin C, Anti-Acrogranin, Anti-Granulin-2, Anti-Granulin-5, Anti-Granulin-4, Anti-Granulin-7, Anti-Granulin-6, Anti-Granulin B, Anti-Granulin-1, Anti-Granulin A, Anti-Granulin F, Anti-Granulin G, Anti-Granulin D, Anti-Granulin E
Supplier: United States Biological
Supplier-Nr: G8944-50B

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Species reactivity: human
Immunogen: Synthetic peptide corresponding to QSKCLSKENATTD, from the internal region of human GRN (NP_002078.1).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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