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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A302-116A-T | 10 µl (2 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A302-116A | 100 µl | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide... more
Product information "Anti-GAPex5"
Protein function: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. [The UniProt Consortium]
Keywords: | Anti-GAPVD1, Anti-GAPEX5, Anti-GAPex-5, Anti-Rab5-activating protein 6, Anti-GTPase-activating protein and VPS9 domain-containing protein 1 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A302-116A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: mouse, bovine) |
Immunogen: | synthetic peptide. The epitope recognized by A302-116A-T maps to a region between residue 700 and 750 of human GTPase activating protein and VPS9 domains 1 using the numbering given in entry BAG10470.1 (GeneID 26130). |
Format: | Antigen Affinity Purified |
Database Information
UniProt ID : | Q14C86 | Matching products |
Gene ID | GeneID 26130 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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