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Anti-FUS

ART NR.: A300-293A (100 µl | 100 µg)

Hersteller: Bethyl

Datenblatt

Anwendungen: WB, IP

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human (expected: rat, bovine, dog, rabbit, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, duckbill platypus, tasmanian devil, white-tufted-ear marmoset, african elephant, chinese hamster, northern white-cheeked gibbon)

Immunogen: synthetic peptide. The epitope recognized by A300-293A maps to a region between residues 400 and 450 of human fusion (involved in t(12,16) in malignant liposarcoma) using the numbering given in SwissProt entry P35637 (GeneID 2521).

Lagerung: +4°C

Versand: +4°C

UniProt ID: P35637 | Suche mit UniProt ID

KEGG ID: K13098 | Suche mit KEGG ID

Schlagworte: Anti-FUS, Anti-Fusion (involved in t(12,16) in malignant liposarcoma), Anti-TLS, Anti-Translocated in liposarcoma protein, Anti-Pigpen, Anti-POMp75.

A300-293A

100 µl (100 µg)

385 €

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Bemerkungen: FUS has been identified as a frequent translocation fusion partner of various transcription factors. FUS fusion genes have been shown to be associated with multiple tumor types which include liposarcoma, leukemia, histocytoma, and sarcoma. FUS is a multifunctional RNA-binding protein that associates with the nuclear matrix and Cajal bodies and appears to play a role in splicesome assembly, pre-mRNA splicing, DNA repair, transcriptional regulation and homologous recombination. Alternate names for FUS include RNA-binding protein FUS, oncogene FUS, oncogene TLS, translocated in liposarcomas, TLS, 75 kDa DNA-pairing protein, POMp75, CHOP, FUS-CHOP, TLS/CHOP, and hnRNP-P2.

Spezifikationen

FUS Antibody

Rabbit anti-FUS Antibody, Affinity Purified
FUS AntibodyFUS AntibodyFUS AntibodyFUS Antibody
FUS AntibodyFUS AntibodyFUS AntibodyFUS Antibody

Gene and Protein Information

Citations

Ward CL, A loss of FUS/TLS function leads to impaired cellular proliferation. Cell Death Dis. 2014 Dec 11;5:e1572. ICC, IF
PubMed: 25501833
Dossi R, Antiangiogenic activity of trabectedin in myxoid liposarcoma: Involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1. Int J Cancer. 2014 Jun 10. IP
PubMed: 24917554
Fujioka Y, FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD. Sci Rep. 2013 Aug 8;3:2388. WB, RIP
PubMed: 23925123
Sama RR, FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress. J Cell Physiol. 2013 Nov;228(11):2222-31. WB
PubMed: 23625794
Ishigaki S et al., Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. Sci Rep. 2012;2:529. IHC-P
PubMed: 22829983
Aoki N et al., Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain. Acta Neuropathol. 2012 Sep;124(3):383-94. WB, IHC-P
PubMed: 22526020
Necchi D et al., Dysfunction of the ubiquitin-proteasome system in the cerebellum of aging Ts65Dn mice. Exp Neurol. 2011 Dec;232(2):114-8. ICC
PubMed: 21867700
Bosco DA et al., Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules. Hum Mol Genet. 2010 Nov 1;19(21):4160-75. WB
PubMed: 20699327
Groen EJ et al., FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands. Arch Neurol. 2010 Feb;67(2):224-30. IHC-P
PubMed: 20142531
Forni C et al., Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. Mol Cancer Ther. 2009 Feb;8(2):449-57. ChIP, WB
PubMed: 19190116
Nash K et al., Identification of cellular proteins that interact with the adeno-associated virus rep protein. J Virol. 2009 Jan;83(1):454-69. ICC, IP
PubMed: 18971280
Goulet I et al., TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. Hum Mol Genet. 2008 Oct 1;17(19):3055-74. WB, ICC
PubMed: 18632687
Hume DA et al., The Ewing sarcoma protein (EWS) binds directly to the proximal elements of the macrophage-specific promoter of the CSF-1 receptor (csf1r) gene. J Immunol. 2008 May 15;180(10):6733-42. ChIP
PubMed: 18453593
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