Anti-FIH-1

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A303-550A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A303-550A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain... more

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Product information "Anti-FIH-1"

Protein function: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. [The UniProt Consortium]

Keywords:	Anti-FIH1, Anti-FIH-1, Anti-HIF1AN, EC=1.14.11.30, Anti-Factor inhibiting HIF-1, Anti-Hypoxia-inducible factor 1-alpha inhibitor, Anti-Hypoxia-inducible factor asparagine hydroxylase
Supplier:	Bethyl Laboratories
Supplier-Nr:	A303-550A

Properties

Application:	WB, IP, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, zebrafish)
Immunogen:	synthetic peptide. The epitope recognized by A303-550A maps to a region between residue 300 and 349 of human Factor Inhibiting HIF-1 using the numbering given in entry NP_060372.2 (GeneID 55662).
Format:	Antigen Affinity Purified