Anti-EZH2

Anti-EZH2
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-196A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A304-196A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex,... more
Product information "Anti-EZH2"
Protein function: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys- 27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer, involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. [The UniProt Consortium]
Keywords: Anti-EZH2, Anti-KMT6, Anti-ENX-1, EC=2.1.1.43, Anti-Enhancer of zeste homolog 2, Anti-Lysine N-methyltransferase 6, Anti-Histone-lysine N-methyltransferase EZH2
Supplier: Bethyl Laboratories
Supplier-Nr: A304-196A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human (Expected: dog, panda, orangutan, rhesus monkey, chimpanzee, white-tufted-ear marmoset, vampire bat, african elephant, crab-eating macaque, northern white-cheeked gibbon, small-eared galago, thirteen-lined ground squirrel)
Immunogen: synthetic peptide. The epitope recognized by A304-196A maps to a region between residue 175 to 225 of human Enhancer of Zeste Homolog 2 using the numbering given in entry CAA64955.1 (GeneID 2146).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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