Anti-EZH2 (Enhancer of Zeste Homolog 2, Histone-lysine N-methyltransferase EZH2, ENX1, ENX-1, KMT6, KMT6A, Lysine N-methyltransferase 6, MGC9169)
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11C1032 |
Rabbit > sec. Ab |
Mab |
IgG |
human, monkey, mouse, rat
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purified |
WB IP IHC IF |
USBio
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E9085-02D.100
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100 µl Buy Bulk |
489 €

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Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. [The UniProt Consortium] Immunogen: Synthetic peptide corresponding to residues surrounding Arg354 of human Ezh2.
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Kat #: E9085-02D.100
Menge: 100 µlBuy Bulk
Preis: 489 €
UniProt ID: Q15910 (Protein knowledgebase) Geninformationen: GeneID 2146
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Schlagworte: EC=2.1.1.43, Anti-Enhancer of zeste homolog 2, antibody, antibodies, Antikörper Loading ...
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Products for: EZH - enhancer of zeste [EC:2.1.1.43]
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