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Anti-EZH2 (Enhancer of Zeste Homolog 2, Histone-lysine N-methyltransferase EZH2, ENX1, ENX-1, KMT6, KMT6A, Lysine N-methyltransferase 6, MGC9169)

ART NR.: E9085-02D.100 (100 µl)

Hersteller: USBio

Datenblatt

Anwendungen: WB, IP, IHC, IF

Format: purified

Klon: 11C1032

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human, monkey, mouse, rat

Immunogen: Synthetic peptide corresponding to residues surrounding Arg354 of human Ezh2.

Lagerung: -20°C

Versand: +4°C

UniProt ID: Q15910
Suche mit UniProt ID

Geninformationen: GeneID 2146

Schlagworte: EC=2.1.1.43, Anti-Enhancer of zeste homolog 2

E9085-02D.100

100 µl

510 €

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Bemerkungen: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. [The UniProt Consortium]

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