16 products were found matching "Cay16625"!

Heneicosapentaenoic Acid (HPA) is a fatty acid present in trace amounts in the green algae Bryopsis pennata Lamouroux and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA) except elongated with one carbon on the carboxyl end, placing the first double bond in the Delta6 position. HPA...

Pellitorine is an amide alkaloid that has been found in P. nigrum and has diverse biological activities. Pellitorine is cytotoxic to HL-60 leukemia and MCF-7 breast cancer cells (IC50s = 13 and 1.8 µg/ml, respectively). It inhibits production of TNF-alpha, IL-1alpha, and IL-1beta and phosphorylation of ERK1/2...

5-Azacytidine is an analog of cytidine which can be incorporated into DNA, inhibit DNA methyltransferases, and cause hypomethylation of cytosine residues in the absence of any significant mutagenic effects. Decitabine is a 2'-deoxy analog of 5-azacytidine which similarly causes hypomethylation of DNA by inhibiting...

Anti-EP4 (Prostaglandin E4) receptor (C-term) conjugated to SureLight(TM) APC, 50µg Antibody: Rabbit anti-EP4 receptor (C-term) IgG Reactivity: Human, murine, rat, and ovine EP4 receptor, non-reactive with EP1, EP2, and EP3 receptors, other species not tested. Excitation max. lambda: 650 nm Emission max. lambda: 660...

GW 788388 is a selective inhibitor of transforming growth factor-beta (TGF-beta) type 1 receptor (TGFBR1 or ALK5, IC50 = 18 nM). It inhibits the expression of collagen type I in cells (IC50 = 93 nM) and in mice when given orally at 10 mg/kg once a day. As TGF-beta stimulates fibrosis in a range of tissues, GW 788388...

7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters, which are capable of forming covalent DNA adducts and inducing mutations.Formal Name: 7,8,9,10-tetrahydro-benzo[a]pyren-7-ol. CAS Number: 6272-55-5. Synonyms: 7-HTBP, NSC...

MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties. This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in...

GPR120 (free fatty acid receptor 4/FFAR4) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. It has been linked to the ability of fatty acids to produce anti-inflammatory effects and to acutely potentiate insulin...

4-Methylumbelliferyl-N-acetyl-alpha-D-neuraminic acid is a fluorogenic substrate of neuraminidases. 4-Methylumbelliferyl-N-acetyl-alpha-D-neuraminic acid is cleaved by neuraminidases to release the fluorescence moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and...

Kanosamine, a constituent of kanamycin, is an antibiotic produced by Streptomyces and Bacillus that can inhibit cell wall synthesis in plant-pathogenic oomycetes (MIC = 25 µg/ml for P. medicaginis M2913) and certain fungi as well as some bacterial species (MIC = 400 µg/ml for S. aureus). It has been explored as an...

3'-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 3 position. It is an abundant oligosaccharide in the milk of many mammals, including cows and humans, particularly postpartum. 3'-Sialyllactose avidly binds several viral strains, including...

SET domain-containing protein 8 (SETD8) is a methyltransferase that selectively monomethylates histone H4 at lysine residue 20 (H4K20), an event proven to have an important role in chromatin structure and transcriptional activation. It is also a regulator of p53, mono-methylating lysine 382 of the tumor suppressor....