Anti-DNMT3A

Anti-DNMT3A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A304-278A-T 10 µl (10 µg) -

2 - 8 business days*

164.00€
A304-278A 100 µl (100 µg) -

2 - 8 business days*

588.00€
 
Protein function: Required for genome-wide de novo methylation and is essential for the... more
Product information "Anti-DNMT3A"
Protein function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [The UniProt Consortium]
Keywords: Anti-Dnmt3a, Anti-DNMT3A, Anti-M.HsaIIIA, EC=2.1.1.37, Anti-DNA MTase HsaIIIA, Anti-DNA methyltransferase HsaIIIA, Anti-DNA (cytosine-5)-methyltransferase 3A
Supplier: Bethyl Laboratories
Supplier-Nr: A304-278A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse (Expected: orangutan, rhesus monkey, gorilla, crab-eating macaque, northern white-cheeked gibbon)
Immunogen: synthetic peptide. The epitope recognized by A304-278A maps to a region between residue 125 to 175 of human DNA (cytosine-5-)-Methyltransferase 3 Alpha using the numbering given in entry NP_783328.1 (GeneID 1788).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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