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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A304-278A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A304-278A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
Protein function: Required for genome-wide de novo methylation and is essential for the... more
Product information "Anti-DNMT3A"
Protein function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. [The UniProt Consortium]
Keywords: | Anti-Dnmt3a, Anti-DNMT3A, Anti-M.HsaIIIA, EC=2.1.1.37, Anti-DNA MTase HsaIIIA, Anti-DNA methyltransferase HsaIIIA, Anti-DNA (cytosine-5)-methyltransferase 3A |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A304-278A |
Properties
Application: | WB, IP, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: orangutan, rhesus monkey, gorilla, crab-eating macaque, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide. The epitope recognized by A304-278A maps to a region between residue 125 to 175 of human DNA (cytosine-5-)-Methyltransferase 3 Alpha using the numbering given in entry NP_783328.1 (GeneID 1788). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K17398 | Matching products |
UniProt ID : | Q9Y6K1 | Matching products |
Gene ID | GeneID 1788 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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