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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay13484-1 | 1 each | - |
6 - 10 business days* |
496.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression,... more
Product information "Anti-DNA Methyltransferase 3a (Clone 64B1446)"
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, three families of mammalian DNA methyltransferase genes have been identified which include DNMT1, DNMT2, and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. DNMT2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The DNMT3 family members, DNMT3a and DNMT3b, are strongly expressed in ES cells but their expression is down regulated in differentiating embyonic stem (ES) cells and is low in adult somatic tissue. It has been shown that naturally occurring mutations of DNMT3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.Synonyms: DNMT3a. Immunogen: recombinant mouse Dnmt3a expressed in bacteria. The epitope was found to be located near the C-terminus (amino acids 705-908). Clone Designation: 64B1446. Formulation: (Request formulation change), 100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Host: Mouse. Isotype: IgG1kappa. Applications: WB, IF/ICC, ChIP, and IHC (paraffin). Origin: Animal/Mouse.
Keywords: | DNMT3a |
Supplier: | Cayman Chemical |
Supplier-Nr: | 13484 |
Properties
Application: | WB, IF/ICC, ChIP, IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | 64B1446 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | mouse |
Immunogen: | recombinant mouse Dnmt3a expressed in bacteria. The epitope was found to be located near the C-terminus (amino acids 705-908) |
Format: | Purified |
Database Information
KEGG ID : | K17398 | Matching products |
UniProt ID : | O88508 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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