Cyclin T2 is a member of the cyclin family of regulatory proteins that associate with and activate cyclin-dependent kinases (CDKs) to regulate cell cycle progression and transcription. The hallmark characteristic of cyclins is the periodicity of their expression and activity that is regulated transcriptionally and post-transcriptionally via phosphorylation and ubiquitination. Cyclin T2 is part of a group of cyclins that are involved in transcriptional regulation at the level of RNA transcription, initiation, elongation, and RNA processing. The transcriptional regulating cyclins include cyclin C, H, K, L1, L2, T1, and T2 which associate with CDK7, -8, -9, -10 and -12. Cyclin T2 associates with CDK9 and is a subunit of the transcription elongation factor p-TEFb. pTEFb is responsible for phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II to facilitate elongation. Alternate names for cyclin T2 include subunit of positive elongation transcription factor b, cycT2, and CCNT2.
Immunogen: synthetic peptide. The epitope recognized by A301-678A maps to a region between residue 680 and 730 of human cyclin T2 using the numbering given in entry NP_490595.1 (GeneID 905).
Kat #: A301-678A
Menge: 100 µl
Preis: 349 €
UniProt ID: O60583 (Protein knowledgebase)
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Anti-CCNT2, Anti-CycT2, Anti-cyclin T2., antibody, antibodies, Antikörper
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Products for: CCNT - cyclin T