17 products were found matching "C8454-12L"!

G1/S-specific cyclin-D2 (CCND2) is a member of the Cyclin family that act as regulators of CDK kinases. CCND2 is essential for the control of the cell cycle at the G1/S transition. Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western...

G1/S-specific cyclin-D2 (CCND2) is a member of the Cyclin family that act as regulators of CDK kinases. CCND2 is essential for the control of the cell cycle at the G1/S transition. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml , Optimal...

G1:S-specific Cyclin-D1 protein is encoded by the CCND1 gene and it belongs to the highly conserved Cyclin Family. Cyclin family members, including G1/S-specific Cyclin-D1, are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclin-D1 acts as an important regulator of...

Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell cycle regulators, and functions in association with cdk4 and / or cdk6 by phosphorylating the Rb protein. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL). Applications: Suitable for use in...

Cyclin D1 gene is identical with the BCL-1 and the PRAD-1 oncogene and is part of the chromosome 11q13 amplicon which is amplified in several common tumor types like breast, lung, esophagus, urinary bladder and head and neck carcinoma. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene...

Applications:, Suitable for use in Cell sorting (FACS analysis), Immunoblot, Immunohistochemistry of frozen and paraffin-embedded sections. Recommended Dilution: Immunohistochemistry: 1:10 in PBS, Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by...

Activity of the cyclin-dependent kinases cdk4 and cdk6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with cdk inhibitors of the Cip/Kip or INK family of proteins (1). In growing cells, the inactive ternary complex of cyclin D/cdk4 and p27...

Cyclin D3 is a G1 cyclin closely related to cyclin D1 and D2. Cyclins D1, D2, and D3 form active kinase complexes in vivo with a distinct subset of cdks, particularly with cdk4 and cdk6. Applications: Suitable for use in Western Blot, Immunohistochemistry, Immunoprecipitation, and Immunocytochemistry. Other...

Applications: , Suitable for use in Flow Cytometry, Immunofluorescence, Immunoprecipitation (will not IP denatured antigen), Western Blotting, Immunohistochemistry (frozen and methanol/Carnoy's or formalin/paraffin). Not recommended for Kinase Assay or Neutralization. Staining of formalin-fixed tissues requires...

Cyclin D3 is a 37kD cell cycle regulatory protein whose expression level and nuclear/cytoplasmic distribution are tightly regulated in synchrony with the cell cycle. Cyclin D3 complexes containing Cdk4 or Cdk6 induce phosphorylation of Rb, a requirement for progression through the G1/S cell cycle transition. Human...

Cyclin D1 is a nuclear protein (36kD ). D type cyclins are predominantly expressed in the G1 phase of the cell cycle. Cyclin D1 study is of interest in various forms of malignancy and over expression has been linked to poor prognosis. Applications: Suitable for use in Flow Cytometry, Immunohistochemistry (frozen and...

CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal...