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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A300-488A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A300-488A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end... more
Product information "Anti-CtIP"
Protein function: Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double- strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end- joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:10764811, PubMed:10910365, PubMed:15485915, PubMed:16581787, PubMed:16818604, PubMed:17965729, PubMed:19202191, PubMed:19759395, PubMed:20064462, PubMed:20829486). During immunoglobulin heavy chain class-switch recombination, promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations. [The UniProt Consortium]
Keywords: | Anti-RIM, Anti-CtIP, Anti-SAE2, Anti-CTIP, Anti-RBBP8, Anti-RBBP-8, EC=3.1.-.-, Anti-DNA endonuclease RBBP8, Anti-CtBP-interacting protein, Anti-Retinoblastoma-binding protein 8, Anti-Retinoblastoma-interacting protein and myosin-like |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A300-488A |
Properties
Application: | WB, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: pig, orangutan, rhesus monkey, chimpanzee, primates, common squirrel monkey, crab-eating macaque, olive baboon, agile gibbon, siamang, bornean orangutan, black-and-white colobus monkey, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide. The epitope recognized by A300-488A maps to a region between residue 850 and the C-terminus (residue 897) of human CtBP Interacting Protein (Retinoblastoma Binding Protein 8) using the numbering given in entry NP_002885.1 (GeneID 5932). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K20773 | Matching products |
UniProt ID : | Q99708 | Matching products |
Gene ID | GeneID 5932 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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