14 products were found matching "C4201-04"!

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved in these processes as regulators of Cdks. Chk1 and Chk2 both functionas essential components in the G2 DNA damage checkpoint by phophorylating...

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including CHK2 (1), p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The checkpoint kinase CHK2 is the mammalian homologue of yeast...

CHK2, a protein kinase that is activated in response to DNA damage, is involved in cell cycle arrest.Mapped on 22q12.1, CHK2 has a potential regulatory region rich in SQ and TQ aa pairs. It regulates BRCA1 function after DNA damage by phosphorylating serine-988 of BRCA11. Additionally, CHK2 can be modified by...

CHK2, a protein kinase that is activated in response to DNA damage, is involved in cell cycle arrest.Mapped on 22q12.1, CHK2 has a potential regulatory region rich in SQ and TQ aa pairs. It regulates BRCA1 function after DNA damage by phosphorylating serine-988 of BRCA11. Additionally, CHK2 can be modified by...

CHK2, a protein kinase that is activated in response to DNA damage, is involved in cell cycle arrest.Mapped on 22q12.1, CHK2 has a potential regulatory region rich in SQ and TQ aa pairs. It regulates BRCA1 function after DNA damage by phosphorylating serine-988 of BRCA11. Additionally, CHK2 can be modified by...

CHK2, a protein kinase that is activated in response to DNA damage, is involved in cell cycle arrest.Mapped on 22q12.1, CHK2 has a potential regulatory region rich in SQ and TQ aa pairs. It regulates BRCA1 function after DNA damage by phosphorylating serine-988 of BRCA11. Additionally, CHK2 can be modified by...

CHK2, a protein kinase that is activated in response to DNA damage, is involved in cell cycle arrest.Mapped on 22q12.1, CHK2 has a potential regulatory region rich in SQ and TQ aa pairs. It regulates BRCA1 function after DNA damage by phosphorylating serine-988 of BRCA11. Additionally, CHK2 can be modified by...

Synthetic peptide (SRESDVEAQQSHGSSAC) corresponding to amino acids 2 to 18 of human CHK2 (1). The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including CHK2 (1), p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2...

Chk2 is the mammalian homologue of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases (1-3). The amino-terminal domain of Chk2 contains a series of seven serine or threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be...

Chk2 is the mammalian homologue of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases (1-3). The amino-terminal domain of Chk2 contains a series of seven serine or threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) followed by glutamine (SQ or TQ motif). These are known to be...

Chk2 (checkpoint kinase 2) is the mammalian homolog of the Saccharomyces cerevisiae Rad53 and is required for the DNA damage and replication checkpoints (1). In response to low-dose ionizing radiation (IR), which occurs in an ataxia telangiectasia mutated (ATM)-dependent manner, Chk2 can phosphorylate the...

Chk2 is the mammalian orthologue of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases. The amino-terminal domain of Chk2 contains a series of seven serine or threonine residues (Ser19, Thr26, Ser28, Ser33, Ser35, Ser50 and Thr68) each followed by glutamine (SQ or TQ motif). These are known to be...