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Anti-Chk1

ART NR.: A300-298A (100 µl / 100 µg)

Hersteller: Bethyl

Datenblatt

Anwendungen: WB, IP, PLA

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human (expected: dog, swine, panda, orangutan, rhesus monkey, gorilla, chimpanzee, small-eared galago, northern white-cheeked gibbon)

Immunogen: synthetic peptide. The epitope recognized by A300-298A maps to a region between residues 250 and 300 of human Checkpoint Kinase 1 using the numbering given in SwissProt entry O14757 (GeneID 1111).

Lagerung: +4°C

Versand: +4°C

UniProt ID: O14757 | Suche mit UniProt ID

KEGG ID: K02216 | Suche mit KEGG ID

Schlagworte: EC=2.7.11.1, Anti-Chk1, Anti-Chk-1, Anti-Chek1, Anti-Checkpoint Kinase 1.

A300-298A

100 µl (100 µg)

393 €

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Bemerkungen: Chk1 functions as a checkpoint protein kinase that is critical to the regulation of the Cdc25a and Cdc25c phosphatases that promote S and G2/M phase progression, respectively. Chk1 kinase activity inhibits cell cycle progression in the presence of DNA damage by phosphorylating Cdc25a and Cdc25c and causing the degradation of Cdc25a and cytoplasmic sequestration of Cdc25c. Alternate designations for Chk1 include serine/threonine-protein kinase Chk1, and CHEK1.

Spezifikationen

Chk1 Antibody

Rabbit anti-Chk1 Antibody, Affinity Purified
Chk1 AntibodyChk1 AntibodyChk1 AntibodyChk1 AntibodyChk1 Antibody
Chk1 AntibodyChk1 AntibodyChk1 AntibodyChk1 AntibodyChk1 Antibody

Gene and Protein Information

Citations

Xie J et al., FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response. PLoS Genet. 2012 Jul;8(7):e1002786. IP, WB
PubMed: 22792074
Yoshioka K et al., ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. Mol Cell. 2006 May 19;22(4):501-10. WB, IP
PubMed: 16713580
Shiotani B et al., Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1. Mol Cancer Res. 2006 Feb;4(2):125-33. WB, IP
PubMed: 16513843

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