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53 Antikörper Treffer

Anti-CDK7, ID (Cell division protein kinase 7, CDK-activating kinase, CAK, TFIIH basal transcription factor complex kinase subunit, 39kD protein kinase, P39 Mo15, STK1, CAK1, CDK7, MO15,)

ART NR.: 033678.200 (200 µl)

Hersteller: USBio

Datenblatt

Anwendungen: ELISA, WB

Format: affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human

Immunogen: CDK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of Human CDK7.

Lagerung: -20°C

Versand: +4°C

UniProt ID: P50613 | Suche mit UniProt ID

Gene ID: Gene ID 1022 | Suche mit Gene ID

KEGG ID: K02202 | Suche mit KEGG ID

Schlagworte: Anti-CAK, Anti-CDK7, Anti-p39 Mo15, EC=2.7.11.23, EC=2.7.11.22, Anti-39 kDa protein kinase, Anti-CDK-activating kinase 1, Anti-Cyclin-dependent kinase 7, Anti-Cell division protein kinase 7, Anti-Serine/threonine-protein kinase 1

033678.200

200 µl

571 €

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Bemerkungen: Protein function: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53, this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition. [The UniProt Consortium]

Spezifikationen

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