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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A300-472A-T | 10 µl (10 µg) | - |
2 - 8 business days* |
164.00€
|
|||
A300-472A | 100 µl (100 µg) | - |
2 - 8 business days* |
588.00€
|
Protein function: Export receptor for importin-alpha. Mediates importin- alpha re-export from the... more
Product information "Anti-CSE1"
Protein function: Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. [The UniProt Consortium]
Keywords: | Anti-CAS, Anti-Exp2, Anti-CSE1L, Anti-Exportin-2, Anti-Importin-alpha re-exporter, Anti-Chromosome segregation 1-like protein, Anti-Cellular apoptosis susceptibility protein |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | A300-472A |
Properties
Application: | WB, IP, IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: bovine) |
Immunogen: | synthetic peptide. The epitope recognized by A300-472A-M maps to a region between residues 1 and 50 of human Chromosome Segregation-1 using the numbering given in entry NP_001307.2 (GeneID 1434). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K18423 | Matching products |
UniProt ID : | P55060 | Matching products |
Gene ID | GeneID 1434 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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