23 products were found matching "C2448-09E"!

CD117 is expressed by some hematopoietic stem cells (approx. 70% of CD34+ve cells in normal bone marrow are CD117+ve), by some acute myeloid leukemias and by mast cells. Functionally CD117 is a receptor for stem cell factor and has receptor tyrosine kinase activity. This antibody is non-neutralizing. Applications:...

CD117 cell surface antigen is a 145kD glycoprotein also known as c-kit. CD117 is expressed by some haematopoietic stem cells (~70% of CD34+ve cells in normal bone marrow are CD117+ve), some acute myeloid leukaemias and by mast cells. Functionally CD117 is a receptor for stem cell factor, and has receptor tyrosine...

The CD117/c-kit antigen is the cell-surface receptor for Stem Cell Factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-kit has an important role in stimulating myeloid and erythroid production of primitive...

c Kit, also known as CD117 and stem cell factor receptor, is a 145kD transmembrane tyrosine kinase encoded by the c Kit proto-oncogene. c Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to...

Human CD117 (c-kit) is a transmembrane protein with receptor tyrosine kinase capacity and serves as the receptor for steel factor (SLF). CD117 is expressed on almost all hematopoietic progenitor cells and receptor/ligand interaction is crucial for development of hematopoietic stem cells. Applications: Suitable for...

CD117 or c-kit, a transmembrane receptor tyrosine kinase, is a receptor for a growth factor encoded by the steel locus and known as steel factor (SLF), stem cell factor (SCF), mast cell growth factor MGF or KIT Ligand (KL). The binding of the stem cell factor (SCF) to the c-kit-encoded receptor tyrosine kinase (Type...

c-Kit is a member of the subfamily of receptor tyrosine kinases that includes PDGF, CSF-1 and FLT3/flk-2 receptors (1,2). It plays a critical role in activation and growth in a number of cell types such as hematopoietic stem cells, mast cells, melanocytes and germ cells (3). Upon binding with its ligand, stem cell...

The CD117/c-kit antigen is the cell-surface receptor for Stem Cell Factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-kit has an important role in stimulating myeloid and erythroid production of primitive...

The CD117/c-kit antigen is the cell-surface receptor for Stem Cell Factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-kit has an important role in stimulating myeloid and erythroid production of primitive...

The CD117/c-kit antigen is the cell-surface receptor for Stem Cell Factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-kit has an important role in stimulating myeloid and erythroid production of primitive...

The CD117/c-kit antigen is the cell-surface receptor for Stem Cell Factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-kit has an important role in stimulating myeloid and erythroid production of primitive...

The CD117/c-kit antigen is the cell-surface receptor for Stem Cell Factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-kit has an important role in stimulating myeloid and erythroid production of primitive...