CD105, also known as Endoglin, is a homodimeric type I transmembrane glycoprotein associated primarily with vascular endothelium. It binds TGF-beta1 and TGF-beta3 efficiently and forms a complex with the TGF-b signaling receptors, TGF-b receptors I and II. CD105 plays important roles in angiogenesis and...

CD105, also known as Endoglin, is a disulfide-linked homodimeric type I transmembrane glycoprotein (1, 2). Two isoforms of CD105, a short form and a long form, differ by 33 aa in their cytoplasmic tails (3). The long form (180kD in size) is considered the predominant form of the protein although both isoforms have...

CD105, also known as Endoglin, is a disulfide-linked homodimeric type I transmembrane glycoprotein (1, 2). Two isoforms of CD105, a short form and a long form, differ by 33 aa in their cytoplasmic tails (3). The long form (180kD in size) is considered the predominant form of the protein although both isoforms have...

CD105, also known as Endoglin, is a disulfide-linked homodimeric type I transmembrane glycoprotein (1, 2). Two isoforms of CD105, a short form and a long form, differ by 33 amino acids (aa) in their cytoplasmic tails (3). The long form (180kD in size) is considered the predominant form of the protein although both...