Anti-Bub3

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-365A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A300-365A	100 µl (100 µg)		-		2 - 8 business days*		600.00€

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Protein function: Has a dual function in spindle-assembly checkpoint signaling and in promoting... more

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Product information "Anti-Bub3"

Protein function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. [The UniProt Consortium]

Keywords:	Anti-BUB3, Anti-Mitotic checkpoint protein BUB3
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-365A

Properties

Application:	WB, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, bovine, orangutan)
Immunogen:	synthetic peptide. The epitope recognized by A300-365A maps to a region between residues 275 and 325 of human Bub3 using the numbering given in Swiss-Prot entry O43684 (GeneID 9184).
Format:	Antigen Affinity Purified