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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| 200-301-902 | 100 µg | - | - |
6 - 10 business days* |
698.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Essential component of the mitotic checkpoint. Required for normal mitosis... more
Product information "Anti-BUBR1 Kinase, clone 8G1"
Protein function: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [The UniProt Consortium]
| Keywords: | Anti-BUB1B, Anti-BUBR1, Anti-hBUBR1, EC=2.7.11.1, Anti-Protein SSK1, Anti-Mitotic checkpoint kinase MAD3L, Anti-MAD3/BUB1-related protein kinase, Anti-Mitotic checkpoint serine/threonine-protein kinase BUB1 beta |
| Supplier: | Rockland Immunochemicals |
| Supplier-Nr: | 200-301-902 |
Properties
| Application: | ELISA, IFM, IP, WB |
| Antibody Type: | Monoclonal |
| Clone: | 8G1 |
| Conjugate: | No |
| Host: | Mouse |
| Species reactivity: | human (Expected: human) |
| Immunogen: | recombinant protein corresponding to amino acids 1-350 of human BUBR1 kinase protein |
Database Information
| KEGG ID : | K06637 | Matching products |
| UniProt ID : | O60566 | Matching products |
| Gene ID | GeneID 701 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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