Anti-BRD2 (Bromodomain-containing Protein 2, O27.1.1, Really Interesting New Gene 3 Protein, KIAA900

Anti-BRD2 (Bromodomain-containing Protein 2, O27.1.1, Really Interesting New Gene 3 Protein, KIAA900
Item number Size Datasheet Manual SDS Delivery time Quantity Price
B2735-01E.100 100 µl - -

3 - 19 business days*

682.00€
 
Brd2 is a highly conserved member of the BET subfamily of bromodomain proteins that contain two... more
Product information "Anti-BRD2 (Bromodomain-containing Protein 2, O27.1.1, Really Interesting New Gene 3 Protein, KIAA900"
Brd2 is a highly conserved member of the BET subfamily of bromodomain proteins that contain two tandem N-terminal bromodomains and a single C-terminal extra-terminal (ET) domain (1). In addition to its involvement in guiding the expression of cell cycle genes through its binding to multiple E2Fs (2), Brd2 has been shown to be associated with several regulators of transcription, including TFIID and Swi/Snf complexes (3,4). First identified as a nuclear serine/threonine kinase (5), Brd2, like other bromodomain proteins, is thought to function in mammalian development by regulating chromatin structure and transcription (6). Brd2 has been shown to bind to histone H4 via acetylated Lys12, a substrate of several histone acetyltransferase transcriptional coactivators (7). In mouse, Brd2 has the highest levels of expression during embryogenesis and in the adult testis, ovaries, and brain (8,9,10). Brd2-deficient mouse embryos exhibit delayed development and eventual death due to neural tube closure defects (11). Mutations in the promoter of the Brd2 gene have been associated with increased susceptibility to juvenile myoclonic epilepsy (JME) (12). Applications: Suitable for use in Western Blot and ChIP. Other applications not tested. Recommended Dilution: Western Blot: 1:1000, ChIP: 1:50, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-Bromodomain-containing protein 2, Anti-Really interesting new gene 3 protein
Supplier: United States Biological
Supplier-Nr: B2735-01E

Properties

Application: WB
Antibody Type: Monoclonal
Clone: D89B4
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse
Immunogen: Synthetic peptide corresponding to residues surrounding Ala310 of human Brd2.
Format: Supernatant

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-BRD2 (Bromodomain-containing Protein 2, O27.1.1, Really Interesting New Gene 3 Protein, KIAA900"
Write a review
or to review a product.
Viewed