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Anti-BRAP

ART NR.: A302-682A (100 µl)

Hersteller: Bethyl

Datenblatt

Anwendungen: WB, IP

Format: antigen affinity purified

Wirt: Rabbit

Isotyp: IgG

Reaktivität: human (expected: dog, panda, orangutan, chimpanzee, small-eared galago, thirteen-lined ground squirrel)

Immunogen: synthetic peptide. The epitope recognized by A302-682A maps to a region between residue 560 and 592 of human BRCA1 associated protein using the numbering given in entry NP_006759.3 (GeneID 8315).

UniProt ID: Q7Z569
Suche mit UniProt ID

Geninformationen: GeneID 8315

Schlagworte: EC=6.3.2.-, Anti-BRAP, Anti-BRCA1 associated protein, Anti-IMP, Anti-impedes mitogenic signal propagation, Anti-RNF52, Anti-RING finger protein 52.

A302-682A

100 µl

349 €

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Bemerkungen: BRCA1-associated protein (BRAP) negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. BRAP acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. BRAP may also act as a cytoplasmic retention protein with a role in regulating nuclear transport. Alternative names for BRAP include BRAP2, impedes mitogenic signal propagation, IMP, RING finger protein 52, renal carcinoma antigen NY-REN-63, and RNF52. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q7Z569]

Spezifikationen

bethyl_datasheet_parse.php?nr=A302-682A&ak=1
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