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Track device being used
![Anti-BHC110/LSD1 (IHC)](https://www.biomol.com/media/image/f1/6d/fd/IHC-00122-T_600x600.jpg)
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00122-T | 10 µl (2500 ng) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00122 | 100 µl (25 µg) | - |
2 - 8 business days* |
623.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9'... more
Product information "Anti-BHC110/LSD1 (IHC)"
Protein function: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr- 6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E- cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. [The UniProt Consortium]
Keywords: | Anti-AOF2, Anti-KDM1A, EC=1.-.-.-, Anti-BRAF35-HDAC complex protein BHC110, Anti-Lysine-specific histone demethylase 1A, Anti-Flavin-containing amine oxidase domain-containing protein 2 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00122 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: orangutan, gorilla) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00122 maps to a region between residues 50 and 100 of human FAD-binding protein BRAF35-HDAC complex 110 kDa using the numbering given in entry BAA25527.1 (GeneID 23028). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K11450 | Matching products |
UniProt ID : | O60341 | Matching products |
Gene ID | GeneID 23028 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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